The syngeneic mouse model is an invaluable tool in cancer research, particularly for studying tumor immunology and evaluating immunotherapies. This model involves transplanting tumor cells from a mouse of a specific strain into another mouse of the same genetic background, ensuring that the recipient’s immune system does not reject the tumor due to genetic disparity. The syngeneic mouse model allows researchers to investigate the interactions between the immune system and tumors in a controlled environment, closely mimicking the complexity of human cancer immune dynamics. It is essential for preclinical testing of new therapies, including immune checkpoint inhibitors and cancer vaccines, providing insights into their efficacy and potential mechanisms of action.
